Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial
This phase II trial of neoadjuvant nivolumab plus carboplatin and paclitaxel in previously untreated, locally-advanced, resectable SCCHN was well tolerated and reached its primary endpoint of pCR at the primary site. A phase III confirmatory study is warranted in advanced-stage, resectable HPV-negative SCCHN.
Authors
- Haresh Naringrekar (ORCID: https://orcid.org/0000-0003-1049-4457)
- Athanassios Argiris (ORCID: https://orcid.org/0000-0003-4075-8812)
- Eric V. Mastrolonardo (ORCID: https://orcid.org/0000-0002-2869-8848)
- Joseph Curry (ORCID: https://orcid.org/0000-0001-9507-4237)
- Adam Luginbuhl (ORCID: https://orcid.org/0000-0001-7682-3108)
- Stacey Gargano (ORCID: https://orcid.org/0000-0002-2780-1866)
- Voichita Bar‐Ad (ORCID: https://orcid.org/0000-0001-6529-0406)
- Richard Andrew Goldman (ORCID: https://orcid.org/0009-0006-5353-1077)
- Andrew Yampolsky (ORCID: https://orcid.org/0000-0002-9807-167X)
- Benjamin E. Leiby (ORCID: https://orcid.org/0000-0003-0761-8383)
- Christopher Fundakowski
- Madalina Tuluc (ORCID: https://orcid.org/0000-0003-4920-3901)
- Pablo Llerena (ORCID: https://orcid.org/0009-0008-1507-9723)
- Zachary Elliott (ORCID: https://orcid.org/0000-0002-3454-3156)
- Dawn Poller
- Jennifer M. Johnson (ORCID: https://orcid.org/0000-0003-4548-307X)
- Charalambos Solomides (ORCID: https://orcid.org/0000-0002-4769-8122)
- David M. Cognetti (ORCID: https://orcid.org/0000-0001-7039-3055)
- Larry A. Harshyne (ORCID: https://orcid.org/0000-0002-8699-3028)
- Ralph Zinner (ORCID: https://orcid.org/0009-0009-6812-5540)
- Kathryn Nunes (ORCID: https://orcid.org/0009-0003-3657-978X)
- Rita Axelrod (ORCID: https://orcid.org/0009-0003-5740-0021)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Kentucky (US)
- Thomas Jefferson University (US)
- Thomas Jefferson University Hospital (US)
- Markey Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2807
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00