A novel tRF-Gly is associated with obesity development through post-transcriptional regulation of lipid metabolism
Our findings demonstrate that tRF‑Gly functions as a key regulator of fat accumulation. By silencing RAC1 via AGO3, tRF‑Gly disrupts RAC1/JNK2/β‑catenin complex assembly, prevents β‑catenin nuclear translocation, and downregulates Wnt/β‑catenin signaling, thereby promoting lipid deposition. This study uncovers a novel epigenetic mechanism by which tRF‑Gly controls fat accumulation and suggests that targeting tRF‑Gly may represent a therapeutic strategy for obesity and related metabolic disorders.
Authors
- Jianfeng Ma
- Mingzhou Li (ORCID: https://orcid.org/0000-0001-8681-7684)
- Linyuan Shen (ORCID: https://orcid.org/0000-0001-6072-3268)
- Dujun Chen
- Tianci Liao
- Mailin Gan (ORCID: https://orcid.org/0000-0001-9900-3559)
- Li Zhu
- Xin Zhang (ORCID: https://orcid.org/0000-0002-8525-3597)
- Lei Chen (ORCID: https://orcid.org/0000-0003-2352-3309)
- Kai Wang
- Yan Wang (ORCID: https://orcid.org/0000-0003-3262-9930)
- Xue Zhao (ORCID: https://orcid.org/0000-0002-0211-3549)
- Yiting Yang (ORCID: https://orcid.org/0000-0002-7331-2772)
- Lili Niu
- Xiaofeng Zhou (ORCID: https://orcid.org/0000-0003-3099-212X)
- Xinyi Wang (ORCID: https://orcid.org/0009-0004-4231-0194)
- Ye Zhao
- Yuhang Lei
Institutions
- Sichuan University (CN)
- Sichuan Agricultural University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Sichuan Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s11658-025-00835-2
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00