Therapeutic mechanism of Pithecellobium clypearia Benth. on imiquimod-induced psoriasis revealed by tissue transcriptomics in mice
P. clypearia may ameliorate inflammation in psoriasis mice by modulating genes such as Hspa1a, Hspa1b, mt-Nd4l, mt-Nd5, mt-Nd6, Bcl2, Asns, Trib3, and associated pathways related to energy metabolism, cell growth, and apoptosis. Our study explored the underlying molecular mechanisms at the transcriptome level and provided a theoretical basis for further investigation into the efficacy of P. clypearia.
Authors
- Xiao-Tao He (ORCID: https://orcid.org/0000-0003-1897-0892)
- Y. J. Mo (ORCID: https://orcid.org/0000-0003-4308-3152)
- Mingmei Zhou (ORCID: https://orcid.org/0000-0002-2552-4754)
- Yuzi Xu (ORCID: https://orcid.org/0000-0003-2097-0293)
- Peixin Shi
- Ting Zhang (ORCID: https://orcid.org/0009-0004-1934-8493)
Institutions
- Guiyang Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1371/journal.pone.0333197
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00