Impact of rAAV-shRNA treatment targeting mechanosensitive Ilk1 and Fermt2 in a mouse model of sepsis-induced muscle weakness
Sepsis induced upregulation of integrin-receptor-complex-related genes but attenuating the upregulation of Ilk1 or Fermt2 did not affect the development of muscle weakness, although muscle fiber size was better preserved, arguing against a key role for Ilk1 or Fermt2.
Authors
- Lies Pauwels
- Sarah Derde (ORCID: https://orcid.org/0009-0005-6724-643X)
- Sarah Vander Perre
- Rik Gijsbers (ORCID: https://orcid.org/0000-0003-0191-3904)
- Lies Langouche (ORCID: https://orcid.org/0000-0002-8564-6809)
- Chris Van den Haute (ORCID: https://orcid.org/0000-0002-6650-3845)
- Katrien Koppo (ORCID: https://orcid.org/0000-0002-6022-1097)
- Alexander Pacolet (ORCID: https://orcid.org/0000-0002-3408-1174)
- Inge Derese
- M.A. Smits (ORCID: https://orcid.org/0009-0004-0997-8993)
Institutions
- Advanced Pharma (US)
- Neuroelectronics Research Flanders (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1371/journal.pone.0338338
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cystinosis Ireland
- Vlaamse regering