Pan-Cancer profiling of ferroptosis-related genes reveals prognostic biomarkers and sex-specific associations
This study provides first evidence of sex-differences in ferroptosis-related gene expression with potential clinical relevance. This pan-cancer resource links ferroptosis-related genes to survival outcomes and highlights <i>SLC7A11</i>, <i>BECN1</i>, and <i>GLS2</i> as high-priority candidates for future mechanistic and clinical studies. Integrating sex as a biological variable into study design and interpretation will enhance clinical relevance.
Authors
- Laure Marignol (ORCID: https://orcid.org/0000-0002-2680-6200)
- Michael S. Samuel (ORCID: https://orcid.org/0000-0001-7880-6379)
Institutions
- Trinity College Dublin (IE)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.ctro.2025.101095
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00