Macrophage Subtypes Distinctly Impact Intervertebral Disc Inflammation and Extracellular Matrix Composition
Inflammatory stimulation of IVDs and co-culture with macrophages in vitro impacted both inflammation and ECM composition. Both macrophage subtypes reversed TNFα-induced changes in collagen content, while M1 and M2 macrophages had detrimental and protective effects on inflammation, respectively. The macrophage-IVD explant co-culture model in this study provides a novel system for evaluating crosstalk exclusively through paracrine signaling.
Authors
- Lauren E. Lisiewski (ORCID: https://orcid.org/0000-0001-9655-7839)
- Min Kyu M. Kim (ORCID: https://orcid.org/0000-0001-8339-7768)
- Leonardo Rodrigues Campos (ORCID: https://orcid.org/0000-0002-1569-7360)
- Timothy Jacobsen (ORCID: https://orcid.org/0000-0001-8944-8095)
- Nadeen O. Chahine (ORCID: https://orcid.org/0000-0002-0478-6042)
Institutions
- Columbia University (US)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jsp2.70143
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Institutes of Health
- Irving Medical Center, Columbia University
- Mega-projects of Science Research for the 10th Five-Year Plan