Intrauterine Exposure to Endocrine-disrupting Chemicals and Risk of Hypospadias: A Pilot Study
This study demonstrated that EDCs were present in meconium samples, supporting the hypothesis that maternal exposure results in fetal exposure during a time of critical fetal urogenital development. Our data suggests a pattern of higher BPA in cases of hypospadias compared to controls while BPA and BPS were inversely related to AGD and SPL. However, the study is limited by small sample size and therefore was underpowered to detect conclusive differences between the 2 groups. Further studies in EDC exposure and genitourinary differences are warranted.
Authors
- Christina P. Carpenter (ORCID: https://orcid.org/0000-0002-4584-0500)
- Khue Vu Nguyen (ORCID: https://orcid.org/0000-0002-9159-809X)
- Beizhan Yan (ORCID: https://orcid.org/0000-0002-1321-779X)
- Cara V. Tillotson (ORCID: https://orcid.org/0000-0001-5552-8505)
- Anna Sonnett Fisher
- Patricia Vuguin (ORCID: https://orcid.org/0000-0002-4982-0400)
- Julie Beth Herbstman (ORCID: https://orcid.org/0000-0001-5531-163X)
- Sharon E. Oberfield (ORCID: https://orcid.org/0000-0001-9652-1107)
- Zoltan Antal (ORCID: https://orcid.org/0000-0001-8471-8930)
Institutions
- Lamont-Doherty Earth Observatory (US)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1210/jendso/bvaf208
- Citations
- 1
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Institutes of Health
- Weill Cornell Medical College
- National Institute of Diabetes and Digestive and Kidney Diseases