Oral Fluid Concentrations of Tenofovir and Emtricitabine for Monitoring HIV Antiretroviral Adherence: Findings From a Randomized Trial with Directly Observed Therapy (TARGET Study)
FTC can be detected in oral fluids and may be a promising pharmacologic marker for identifying recent PrEP non-adherence as early as one dose missed. TFV had lower concentrations in oral fluids, and is not suitable for adherence monitoring. <b>Clinical Trials Registration.</b> NCT0301260.
Authors
- Xin Niu (ORCID: https://orcid.org/0000-0002-9136-3434)
- Tim Roy Cressey (ORCID: https://orcid.org/0000-0002-8106-0974)
- Tiancheng Edwards
- Paul K. Drain (ORCID: https://orcid.org/0000-0002-9569-4097)
- Oraphan Siriprakaisil
- Pra-ornsuda Sukrakanchana (ORCID: https://orcid.org/0000-0002-3292-0499)
- Richard E. Haaland (ORCID: https://orcid.org/0000-0001-8165-3879)
- Jeannette A Dienhart
Institutions
- Centers for Disease Control and Prevention (US)
- University of Liverpool (GB)
- University of Washington (US)
- Health Alliance International (US)
- SanPaTong Hospital (TH)
- Chiang Mai University (TH)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1093/ofid/ofaf766
- Primary Topic
- HIV/AIDS oral health manifestations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases