Long-Term Effectiveness of Tenofovir Alafenamide Versus Entecavir in Treatment-Naive Chronic Hepatitis B: A Real-World Evidence from the Global Alliance for the Study of Hepatitis B Virus
BR rates were similar with ETV and TAF, while VR and CR were higher with TAF, although the difference was modest (<5% overall, 7%-9% in high HBV DNA or ALT groups). Antiviral selection between TAF vs ETV should be based mainly on cost, side effect profile, and patient preference.
Authors
- Pei‐Chien Tsai (ORCID: https://orcid.org/0000-0002-5044-6727)
- Takashi Honda (ORCID: https://orcid.org/0000-0001-8951-0952)
- Seng Gee Lim (ORCID: https://orcid.org/0000-0003-0994-4932)
- Norio Itokawa (ORCID: https://orcid.org/0009-0002-2390-6692)
- Wan‐Long Chuang (ORCID: https://orcid.org/0000-0002-2376-421X)
- Yasuhito Tanaka (ORCID: https://orcid.org/0000-0002-2473-6966)
- Wenjing Ni (ORCID: https://orcid.org/0000-0001-5241-2304)
- Chao Wu (ORCID: https://orcid.org/0000-0002-1657-010X)
- Ramsey Cheung (ORCID: https://orcid.org/0000-0002-0211-7013)
- Hidenori Toyoda (ORCID: https://orcid.org/0000-0002-1652-6168)
- Adrian Carlos Gadano (ORCID: https://orcid.org/0000-0002-3590-2472)
- Tomonori Senoh
- Mindie H. Nguyen (ORCID: https://orcid.org/0000-0002-6275-4989)
- Jie Li (ORCID: https://orcid.org/0000-0002-6912-3346)
- Chia‐Yen Dai (ORCID: https://orcid.org/0000-0003-2296-3054)
- Jee‐Fu Huang (ORCID: https://orcid.org/0000-0002-2752-7051)
- Ritsuzo Kozuka (ORCID: https://orcid.org/0000-0002-0763-6760)
- Ei Itobayashi (ORCID: https://orcid.org/0000-0003-0475-2819)
- Fajuan Rui (ORCID: https://orcid.org/0009-0006-4895-2248)
- Philip Vutien (ORCID: https://orcid.org/0000-0002-4196-6077)
- Ming‐Lun Yeh (ORCID: https://orcid.org/0000-0003-3728-7618)
- Sebastián Marciano (ORCID: https://orcid.org/0000-0002-7983-1450)
- Chung‐Feng Huang (ORCID: https://orcid.org/0000-0002-3367-068X)
- Haruki Uojima
- S. Van Der Linden (ORCID: https://orcid.org/0000-0003-1810-0790)
- Kazuhiro Takahashi (ORCID: https://orcid.org/0000-0003-1900-4389)
- Ming‐Lung Yu (ORCID: https://orcid.org/0000-0001-8145-1900)
- Toru Ishikawa (ORCID: https://orcid.org/0000-0002-5470-9694)
- Takanori Ito (ORCID: https://orcid.org/0000-0002-2594-0854)
- Akito Nozaki (ORCID: https://orcid.org/0000-0002-3310-6632)
- Angela Chau (ORCID: https://orcid.org/0000-0001-9863-6370)
- Tsunamasa Watanabe (ORCID: https://orcid.org/0000-0002-7659-914X)
- Koichi Takaguchi (ORCID: https://orcid.org/0000-0003-0175-8721)
- Manabu Morimoto (ORCID: https://orcid.org/0009-0006-7576-7187)
- Masaru Enomoto (ORCID: https://orcid.org/0000-0002-4028-4381)
- Hiroshi Abe
- Joanne Kimiko Liu (ORCID: https://orcid.org/0000-0002-3457-8519)
- Yixuan Zhu (ORCID: https://orcid.org/0000-0003-0669-5918)
- Masanori Atsukawa
- Huy N. Trinh
- Kaori Inoue (ORCID: https://orcid.org/0009-0007-8770-2011)
- Mayumi Maeda (ORCID: https://orcid.org/0000-0001-6946-5082)
- Kunihiko Tsuji
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- St. Marianna University School of Medicine (JP)
- National University of Singapore (SG)
- Saga University (JP)
- University of Washington (US)
- VA Palo Alto Health Care System (US)
- Cornell University (US)
- Yokohama City University Medical Center (JP)
- Hospital Italiano de Buenos Aires (AR)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Kanagawa Prefectural Hospital Organization (JP)
- Nagoya City University (JP)
- National Center for Global Health and Medicine (JP)
- Saiseikai Niigata Daini Hospital (JP)
- Nanjing Drum Tower Hospital (CN)
- Ogaki Municipal Hospital (JP)
- Shinmatsudo Central General Hospital (JP)
- Stanford Medicine (US)
- Teine Keijinkai Hospital (JP)
- Asahi General Hospital (JP)
- National University Hospital (SG)
- Kagawa Prefectural Central Hospital (JP)
- Universidad Hospital Italiano (AR)
- Kanagawa Cancer Center
- Osaka Metropolitan University (JP)
- Weill Cornell Medicine (US)
- Nagoya University (JP)
- Kitasato University (JP)
- Tokyo Metropolitan University (JP)
- Nippon Medical School (JP)
- Nanjing University (CN)
- Yokohama City University (JP)
- Kumamoto University (JP)
- Stanford University (US)
- The University of Osaka (JP)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.14309/ajg.0000000000003881
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00