Will prothrombin complex concentrate replace plasma in cardiac surgical bleeding in North America?
The use of 4F-PCC for the treatment of coagulopathic bleeding in cardiac surgery is supported by high-quality clinical evidence. Several unanswered questions remain regarding sex- and race-specific efficacy, the mechanism through which 4F-PCC may reduce serious adverse events, and its use in procedures that were under-represented in existing clinical trials.
Authors
- Kenichi A. Tanaka (ORCID: https://orcid.org/0000-0002-5051-1365)
- Nadia Gabarin (ORCID: https://orcid.org/0000-0002-9664-7882)
- Justyna Bartoszko (ORCID: https://orcid.org/0000-0002-0738-0451)
- Jeannie Callum
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Women's College Hospital (CA)
- Kingston Health Sciences Centre (CA)
- Pain and Rehabilitation Medicine (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Current Opinion in Anaesthesiology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1097/aco.0000000000001602
- Citations
- 1
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 1.55