Why Did Treg and Immune Tolerance Win Nobel Prize This Year?
From the 1995 identification of CD4CD25 regulatory T (Treg) cells by Shimon Sakaguchi to the 2025 tolling of Stockholm's bells, this "minority population" has moved to center stage in immune tolerance.Recounted here from a first-hand perspective are the pivotal milestones in the Treg chronicle.Each experiment addressed a single question: why does the immune system refrain from attacking self?In jointly honoring the discoverers of Treg cells (Shimon Sakaguchi) and their master regulator
Authors
- Song Guo Zheng (ORCID: https://orcid.org/0000-0002-5611-4774)
Institutions
- Songjiang District Central Hospital (CN)
Publication Details
- Journal
- Genomics Proteomics & Bioinformatics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/gpbjnl/qzaf124
- Primary Topic
- Historical Medical Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00