Mesangial Cell–Derived Extracellular Matrix Protein 1 Is Essential for Maintaining Mesangial Matrix Homeostasis and Glomerular Architecture
ECM1 was highly expressed in glomerular mesangial cells. Loss of Ecm1 led to altered mesangial matrix composition, matrix expansion, and glomerular abnormalities, while restoration of ECM1 expression reversed these defects, demonstrating an essential role of mesangial cell-derived ECM1 in preserving normal mesangial homeostasis and glomerular structure in mice.
Authors
- Yinyin Li (ORCID: https://orcid.org/0000-0001-6195-8309)
- Enguang Bi (ORCID: https://orcid.org/0000-0003-0850-8135)
- Fan Fan Hou (ORCID: https://orcid.org/0000-0003-3117-7418)
- Bing Sun (ORCID: https://orcid.org/0000-0001-5917-3094)
- Jing Nie (ORCID: https://orcid.org/0000-0003-1002-5562)
- Pei Deng
- Danyan Zhang (ORCID: https://orcid.org/0000-0002-0233-494X)
- Yu Hu (ORCID: https://orcid.org/0000-0002-9511-9383)
- Jieli Yu
- Hui Zhou (ORCID: https://orcid.org/0000-0003-2926-5734)
- Lingling Gao (ORCID: https://orcid.org/0000-0003-2944-1865)
- Jiao Luo (ORCID: https://orcid.org/0000-0002-7583-8209)
- Miaomiao Zhou (ORCID: https://orcid.org/0000-0002-5609-2341)
- Fang Yang (ORCID: https://orcid.org/0000-0002-1387-2399)
- Nannan Guo (ORCID: https://orcid.org/0009-0006-9212-9670)
Institutions
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Ministry of Education (RW)
- Cell Technology (China) (HK)
- Center for Excellence in Molecular Cell Science (CN)
- Peking University First Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1681/asn.0000000969
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00