Proton Radiotherapy Alone versus Combined with Immunotherapies or Tyrosine Kinase Inhibitors for Barcelona Clinic Liver Cancer Stage B or C Hepatocellular Carcinoma
In BCLC stage B/C HCC, proton radiotherapy combined with immunotherapy was significantly associated with higher OS, TTP, and DMFS without an increase in grade ≥3 toxicity compared with proton radiotherapy alone or Proton-TKIs.
Authors
- Chao-Wei Lee
- James Welsh
- Hao‐Chien Hung (ORCID: https://orcid.org/0000-0001-8830-3679)
- Yi‐Chung Hsieh (ORCID: https://orcid.org/0000-0002-1191-4399)
- Hong‐Shiue Chou (ORCID: https://orcid.org/0000-0002-3583-2048)
- Shen‐Yen Lin
- Jin‐Chiao Lee (ORCID: https://orcid.org/0000-0001-6075-8786)
- Chia‐Hsun Hsieh (ORCID: https://orcid.org/0000-0002-5547-409X)
- Chen‐Yang Huang (ORCID: https://orcid.org/0000-0002-6767-0389)
- W Chen (ORCID: https://orcid.org/0009-0004-9814-6872)
- Chih‐Hsien Cheng (ORCID: https://orcid.org/0000-0002-3110-1598)
- Tony Kuo (ORCID: https://orcid.org/0000-0002-4120-8559)
- Kun‐Ming Chan (ORCID: https://orcid.org/0000-0002-7566-0113)
- Cheng‐En Hsieh (ORCID: https://orcid.org/0000-0002-2038-4537)
- Chung‐Wei Su (ORCID: https://orcid.org/0000-0003-2778-3618)
- Khoa Tran (ORCID: https://orcid.org/0000-0002-8113-1453)
- Yu‐Chen Chang (ORCID: https://orcid.org/0000-0002-7159-7794)
- Chia-Hsin Lin
- Ting‐Jung Wu
- Tse-Ching Chen
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Chang Gung University (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Liver Cancer
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1159/000550067
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, India
- Chang Gung Medical Foundation
- National Health Research Institutes
- National Science and Technology Council