Dual-target hUCMSCs/EVs therapy for autism spectrum disorder: remodeling gut microbiota and modulating neuroimmune crosstalk in a valproic acid-induced C57BL/6 mice model
These results highlight that although individual treatments offer partial relief, only the combined strategy fully restores neuroimmune-microbiota homeostasis, demonstrating a complementary and synergistic therapeutic effect. This study establishes a novel dual-target approach leveraging systemic hUCMSCs and CNS-targeted EVs, providing a promising translational strategy for ASD through orchestrated regulation of the neuro-immune-microbiota axis.
Authors
- Caixia Wu
- Zhaoming Liu (ORCID: https://orcid.org/0000-0001-9146-4502)
- Xianjie Li (ORCID: https://orcid.org/0000-0002-2749-5352)
- Guanzhen Lin
- Han Wang (ORCID: https://orcid.org/0000-0003-2482-1818)
- Xiaoya Yang (ORCID: https://orcid.org/0009-0002-2727-6544)
Institutions
- Chinese Academy of Sciences (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Guangdong Academy of Sciences (CN)
- Guangzhou Vocational College of Science and Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s13287-025-04829-x
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00