Undetected rifampicin-resistant tuberculosis associated with rpoB I491F and V170F mutations in Botswana: Diagnostic implications
These results highlight a diagnostic gap within the current algorithms and show the value of sequencing-based approaches for accurately detecting drug resistance. Incorporating sequencing into routine clinical practice could help guide the selection of TB treatment and improve treatment outcomes in patients who do not respond to first-line therapy.
Authors
- Rosemary Musonda (ORCID: https://orcid.org/0009-0009-9937-6908)
- Simani Gaseitsiwe (ORCID: https://orcid.org/0000-0002-7089-3735)
- Robin M. Warren (ORCID: https://orcid.org/0000-0001-5741-7358)
- Tuelo Mogashoa (ORCID: https://orcid.org/0000-0003-4156-8746)
- Anzaan Dippenaar (ORCID: https://orcid.org/0000-0002-2511-7534)
- Johannes Loubser (ORCID: https://orcid.org/0000-0002-2362-0187)
- Elizabeth M. Streicher (ORCID: https://orcid.org/0000-0003-3901-1981)
- Kedumetse Seru (ORCID: https://orcid.org/0009-0005-9456-6367)
- Tuduetso Molefi
- Justice Trésor Ngom (ORCID: https://orcid.org/0000-0001-9437-1483)
- Stephen Osei-Wusu (ORCID: https://orcid.org/0000-0003-2840-3568)
- Sikhulile M. Moyo (ORCID: https://orcid.org/0000-0003-3821-4592)
Institutions
- South African Medical Research Council (ZA)
- University of Antwerp (BE)
- University of Botswana (BW)
- Stellenbosch University (ZA)
- Botswana Vaccine Institute (Botswana) (BW)
- Ministry of Health (BW)
- Botswana Harvard AIDS Institute Partnership (BW)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.jgar.2025.12.005
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00