Safety and efficacy of direct oral anticoagulants in patients with liver cirrhosis: a meta-analysis
Based on the findings of this meta-analysis, DOACs may be associated with a reduced risk of major bleeding compared with vitamin K antagonists or low-molecular-weight heparin in patients with liver cirrhosis, including those with CP class B and C cirrhosis. The results of this meta-analysis should be interpreted in the context of methodological limitations. Future analysis should evaluate the impact of specific DOACs and dosage on safety outcomes in this patient population.
Authors
- Ali Eshaghpour (ORCID: https://orcid.org/0000-0002-7827-5827)
- Daniel Tham (ORCID: https://orcid.org/0000-0003-3531-6243)
- Rong Kou (ORCID: https://orcid.org/0000-0002-7801-5793)
- Shreyas Sreeraman (ORCID: https://orcid.org/0000-0003-2443-2441)
- Li Py
- Jennifer Kherani (ORCID: https://orcid.org/0009-0003-0198-4443)
- Yu Wang (ORCID: https://orcid.org/0000-0003-0975-8937)
- Lanjian Zhao
- Mark Crowther (ORCID: https://orcid.org/0009-0004-6072-7735)
- L. Pe a
Institutions
- Western University (CA)
- University of Ottawa (CA)
- University of Toronto (CA)
- McMaster University (CA)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1016/j.rpth.2025.103296
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00