miR-494 Deletion Improves Glucose Metabolism Independently of Obesity in Mice
Browning of white adipose tissue enhances energy expenditure and may improve metabolic health; however, it remains unclear whether inhibition of its suppressor, miRNA-494 (miR-494), can exert therapeutic effects in vivo. We investigated whether genetic deletion of miR-494 expression in vivo promotes adipocyte browning, exerts antiobesity effects, and improves glucose tolerance. miR-494-knockout mice showed resistance to high-fat diet-induced obesity and improved glucose tolerance, even under normal chow feeding conditions. miR-494 inhibition may offer a therapeutic strategy for improving glycemic control through both insulin-dependent and insulin-independent mechanisms, independently of changes in body weight.
Authors
- Yukihiro Fujita (ORCID: https://orcid.org/0000-0003-3238-8743)
- Shinji Kume (ORCID: https://orcid.org/0000-0001-6937-9715)
- Lucia Sugawara
- Itsuko Miyazawa (ORCID: https://orcid.org/0000-0001-6310-7225)
- Satoshi Ugi (ORCID: https://orcid.org/0000-0001-5848-0666)
- Tsuyoshi Yanagimachi
- Hiroshi Maegawa (ORCID: https://orcid.org/0000-0002-4611-8149)
- Shogo Ida (ORCID: https://orcid.org/0000-0003-3165-3867)
- Katsutaro Morino (ORCID: https://orcid.org/0000-0003-2420-3817)
- Seiya Mizuno (ORCID: https://orcid.org/0000-0002-6740-5817)
- Satoru Takahashi (ORCID: https://orcid.org/0000-0001-9595-6467)
- Hirotaka Iwasaki (ORCID: https://orcid.org/0000-0002-0528-4263)
- Takeshi Imamura
- Koichiro Murata
- Natsuko Ohashi
- Mengistu Lemecha
Institutions
- Kagoshima University (JP)
- University of Tsukuba (JP)
- Hirosaki University (JP)
- Hampton University (US)
- Shiga University of Medical Science (JP)
- University of California, Los Angeles (US)
- Tsukuba Medical Center Hospital (JP)
- Tottori University (JP)
Publication Details
- Journal
- Diabetes
- Published
- 2025-12-12
- DOI
- https://doi.org/10.2337/db25-0355
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00