Molecular epidemiology and genetic diversity of <i>Aspergillus</i> species in Chronic Pulmonary Aspergillosis patients from South India
Chronic pulmonary aspergillosis (CPA) comprises a spectrum of lung disorders caused by ubiquitous fungi of the genus Aspergillus, with Aspergillus fumigatus being the most frequently identified pathogen. The disease is globally prevalent and associated with significant morbidity and mortality. Here, we investigated the species distribution, antifungal susceptibility and genetic relatedness of Aspergillus isolates from CPA patients and environmental sources in South India. All tested isolates were susceptible to common antifungals, and A. fumigatus was overall the most common species. Isolates from patients and the environment occasionally displayed identical genotypes, suggesting CPA patients acquire the disease from the environment.
Authors
- Arghadip Samaddar (ORCID: https://orcid.org/0000-0002-4444-4274)
- Theun de Groot (ORCID: https://orcid.org/0000-0001-5841-6461)
- Eelco F. J. Meijer (ORCID: https://orcid.org/0000-0002-0226-024X)
- Bram Spruijtenburg (ORCID: https://orcid.org/0000-0002-6734-361X)
- Prabhat Pramanik (ORCID: https://orcid.org/0000-0001-7075-8050)
- Jacques F. G. M. Meis (ORCID: https://orcid.org/0000-0003-3253-6080)
Institutions
- Radboud University Nijmegen (NL)
- University of Cologne (DE)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Medical Mycology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/mmy/myaf114
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.40