Retinal Impairments in Mice Lacking Both <i>Nxnl1</i> and <i>Nxnl2</i> Genes
Nxnl1-/-Nxnl2-/- mice showed more severe structural and functional retinal deficits compared to the other groups at all ages, indicating that Nxnl1 and Nxnl2 exert non-redundant and/or complementary roles in maintaining photoreceptor function. These findings suggest that the combined products of Nxnl genes may yield more effective therapies for RP.
Authors
- Imen Harichane
- Isabelle S. Audo (ORCID: https://orcid.org/0000-0003-0698-5309)
- Thierry Léveillard (ORCID: https://orcid.org/0000-0001-5692-8770)
- Thérèse Cronin (ORCID: https://orcid.org/0000-0002-2938-2765)
- José‐Alain Sahel (ORCID: https://orcid.org/0000-0002-4831-1153)
- Emmanuelle Clérin (ORCID: https://orcid.org/0000-0003-1451-6051)
- Christina Zeitz (ORCID: https://orcid.org/0000-0002-3510-1712)
- Zheng Li (ORCID: https://orcid.org/0000-0002-7060-2213)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Inserm (FR)
- University of Pittsburgh (US)
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Sorbonne Université (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1167/iovs.66.15.42
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Sorbonne Université