Selenium supplementation in individuals with newly diagnosed Graves’ hyperthyroidism: a double-blind, multi-centre RCT
In individuals with newly diagnosed Graves' hyperthyroidism, daily supplementation with selenium did not have any effects compared with placebo as add-on to standard antithyroid drugs. The GRASS trial findings do not support the use of selenium supplementation in Graves' hyperthyroidism.
Authors
- Tina Vilsbøll (ORCID: https://orcid.org/0000-0002-0456-6787)
- Thilo Samson Chillon (ORCID: https://orcid.org/0000-0001-7706-7906)
- Per Karkov Cramon (ORCID: https://orcid.org/0000-0003-1065-6225)
- Jeppe Gram (ORCID: https://orcid.org/0000-0003-2584-1132)
- Julie Lyng Forman (ORCID: https://orcid.org/0000-0001-7368-0869)
- Lutz Schomburg (ORCID: https://orcid.org/0000-0001-9445-1555)
- Jakob Bue Bjørner (ORCID: https://orcid.org/0000-0001-7033-8224)
- Camilla Bøgelund Larsen (ORCID: https://orcid.org/0000-0002-7342-8660)
- László Hegedüs (ORCID: https://orcid.org/0000-0002-9691-7619)
- Pernille Bach-Mortensen (ORCID: https://orcid.org/0009-0002-1279-6627)
- Kristian Hillert Winther (ORCID: https://orcid.org/0000-0001-5210-4029)
- Anders Juul (ORCID: https://orcid.org/0000-0002-0534-4350)
- Torquil Watt (ORCID: https://orcid.org/0000-0002-6001-7440)
- Kamil Demircan (ORCID: https://orcid.org/0000-0003-2256-7019)
- Rúna Louise Mortansdóttir Nolsöe
- Selma Flora Nordqvist
- Birte Nygaard (ORCID: https://orcid.org/0000-0002-9540-4950)
- Victor Brun Boesen (ORCID: https://orcid.org/0000-0003-2792-6738)
- Steen Joop Bonnema (ORCID: https://orcid.org/0000-0002-6898-1752)
- Ulla Feldt‐Rasmussen (ORCID: https://orcid.org/0000-0002-5903-3355)
- Åse Krogh Rasmussen (ORCID: https://orcid.org/0000-0002-9729-4767)
- Alin Andries
- Nils Knudsen
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Novo Nordisk (Denmark) (DK)
- Frederiksberg Hospital (DK)
- Odense University Hospital (DK)
- Herlev Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1530/etj-25-0264
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Danmarks Frie Forskningsfond
- Forsknings- og Innovationsstyrelsen
- Danish Agency for Science and Higher Education