Lactose-Modified Hyaluronic Acid Molecule Attenuates In Vitro Chondrocyte Inflammation
Hylach<sup>®</sup> exerts an early and more potent anti-inflammatory effect in inflamed 2D and 3D chondrocyte cultures when compared to HA. These findings suggest that targeting Gal-3 through selective HA derivatives may represent a promising strategy for modulating both inflammation and matrix remodelling in OA.
Authors
- Valentina Masola (ORCID: https://orcid.org/0000-0003-2341-2481)
- Alice Donato
- Elisa Belluzzi (ORCID: https://orcid.org/0000-0003-1129-2574)
- Pietro Ruggieri (ORCID: https://orcid.org/0000-0001-9617-9882)
- Paola Brun (ORCID: https://orcid.org/0000-0002-4204-3549)
Institutions
- University of Padua (IT)
- Veneto Institute of Molecular Medicine (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Cells
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3390/cells14241977
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00