A prospective observational study of pancreatic cancer risk in men and women with pathogenic variants in BRCA1 or BRCA2

BRCA1/2 carriers had three times more cases of PC than expected, suggestively higher among female BRCA2 and male BRCA1 carriers. Cumulative risk of PC at 70 years in the latter two groups was less than 3% (0.5% and 0.7% in all Norwegian males and females observed until age 70 based on population data).

Authors

Sigrid Tronsli Hovland
Eli Marie Grindedal (ORCID: https://orcid.org/0000-0002-8198-1706)
Tom K. Grimsrud (ORCID: https://orcid.org/0000-0003-0425-043X)
Manuela Zucknick (ORCID: https://orcid.org/0000-0003-1317-7422)
Lovise Mæhle

Institutions

Oslo University Hospital (NO)
Norwegian Institute of Public Health (NO)
University of Oslo (NO)
Cancer Registry of Norway (NO)

Publication Details

Journal: BJC Reports
Published: 2025-12-12
DOI: https://doi.org/10.1038/s44276-025-00199-2
Primary Topic: BRCA gene mutations in cancer
Type: article
Field-Weighted Citation Impact: 0.00

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article

A prospective observational study of pancreatic cancer risk in men and women with pathogenic variants in BRCA1 or BRCA2

Sigrid Tronsli Hovland, Eli Marie Grindedal, Tom K. Grimsrud, Manuela Zucknick et al.

Dec 12, 2025

BJC Reports

BRCA gene mutations in cancer

article

A prospective observational study of pancreatic cancer risk in men and women with pathogenic variants in BRCA1 or BRCA2

Sigrid Tronsli Hovland, Eli Marie Grindedal, Tom K. Grimsrud, Manuela Zucknick, Lovise Mæhle

December 12, 2025article en

Abstract

BRCA1/2 carriers had three times more cases of PC than expected, suggestively higher among female BRCA2 and male BRCA1 carriers. Cumulative risk of PC at 70 years in the latter two groups was less than 3% (0.5% and 0.7% in all Norwegian males and females observed until age 70 based on population data).

BJC ReportsVol. 3(1)

Oslo University Hospital (NO), Norwegian Institute of Public Health (NO), University of Oslo (NO), Cancer Registry of Norway (NO)

Openalex Percentile: Top 58%

BRCA gene mutations in cancer

DOI Open Access PDF OpenAlex

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A prospective observational study of pancreatic cancer risk in men and women with pathogenic variants in BRCA1 or BRCA2 — Sigrid Tronsli Hovland, Eli Marie Grindedal, et al. · BJC Reports (2025) | TGRS Research Map | TGRS