Rational engineering of an antifreeze-based biomaterial with dual-enhanced ice-binding and delivery for high-efficiency cryopreservation
Through rational design, we converted a natural AFP into a high-performance bioactive material that enables efficient cryopreservation of multiple cell lines. This DMSO-free strategy addresses key limitations of traditional methods, offering a valuable alternative for biomedical use.
Authors
- Sahibzada Muhammad Aqeel (ORCID: https://orcid.org/0000-0003-3798-2514)
- Fei Pan (ORCID: https://orcid.org/0000-0001-9898-1238)
- Yishan Fu
- Jian Chen (ORCID: https://orcid.org/0000-0003-0961-7317)
- Song Liu (ORCID: https://orcid.org/0000-0002-6876-5259)
- Yanfeng Liu (ORCID: https://orcid.org/0000-0002-0562-9647)
Institutions
- Jiangnan University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Apiculture Research (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.008
- Primary Topic
- Physiological and biochemical adaptations
- Type
- article
- Field-Weighted Citation Impact
- 0.00