Exploration of the mechanism of the Mongolian medicine Tonglaga-5 (-5) for the treatment of n-methyl-n'-nitro-n-nitrosoguanidine-induced chronic atrophic gastritis based on network pharmacology and metabolomics.
TLG-5 exerts a therapeutic effect on CAG by regulating β-alanine metabolism, pyrimidine metabolism pathways, and inhibiting the PI3K-AKT signaling pathway and HIF-1 signaling pathways.
Authors
- Xiao-Yu Hu
- Xin Wen Dong (ORCID: https://orcid.org/0000-0003-3709-0655)
- Peifeng Xue (ORCID: https://orcid.org/0000-0002-5702-5263)
- Haibo Wang (ORCID: https://orcid.org/0000-0003-0955-9532)
- Ziqi Cheng (ORCID: https://orcid.org/0000-0001-7519-7301)
- Yuewu Wang (ORCID: https://orcid.org/0000-0002-1158-879X)
- Dan Xue (ORCID: https://orcid.org/0009-0006-8811-1128)
- Temuribagen
- X U Caimeng
- H U Shaonan
- Chen Qianwen
Institutions
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.20250508.001
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00