Impact of Diabetes Mellitus in TB Patients on TB Transmission
In this cohort study, diabetes mellitus in index patients did not increase the risk of TB infection among HHCs and was instead associated with a substantially lower risk of incident TB disease. These findings challenge the prevailing assumption that DM uniformly amplifies transmission due to its association with smear positivity and cavitary disease, suggesting that its influence on TB dynamics may be more complex than previously understood.
Authors
- Megan Murray (ORCID: https://orcid.org/0000-0003-0443-1986)
- Jerome Timothy Galea (ORCID: https://orcid.org/0000-0001-8732-6959)
- Chuan-Chin Huang (ORCID: https://orcid.org/0000-0002-8775-3755)
- A. Madden (ORCID: https://orcid.org/0009-0006-7735-8854)
- Leonid Lecca (ORCID: https://orcid.org/0000-0003-1363-3985)
- Judith Jiménez (ORCID: https://orcid.org/0000-0001-7633-8401)
- Carmen Contreras (ORCID: https://orcid.org/0000-0001-6184-3819)
- Róger Calderón (ORCID: https://orcid.org/0000-0001-8932-0489)
- Rosa Yataco (ORCID: https://orcid.org/0000-0002-4776-8733)
- Zibiao Zhang (ORCID: https://orcid.org/0000-0002-1195-2483)
- Qi Tan (ORCID: https://orcid.org/0000-0001-6854-9778)
- Nicole C. Howard (ORCID: https://orcid.org/0000-0003-0805-5914)
- Mercedes C. Becerra
Institutions
- Brigham and Women's Hospital (US)
- Partners In Health (US)
- Harvard University (US)
- Universidad de San Martín de Porres (PE)
- University of South Florida (US)
- EsSALUD (PE)
- Harvard Global Health Institute (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1093/cid/ciaf647
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00