Subcortical alterations following pediatric posterior fossa brain tumor treatment: A longitudinal MRI study
These findings suggest that children who received treatment for low- or high-grade tumors had different subcortical volumes over time, which may be related to treatment, complications, or demographic factors such as age and sex. These results suggest that while brain tumor treatment primarily aims to cure patients, it may inevitably affect neural development and may contribute to a range of cognitive, behavioral, and emotional long-term deficits. This emphasizes the need for long-term monitoring and prospective longitudinal studies into structural and functional brain changes after treatment for pediatric brain tumor.
Authors
- Marta Fiocco (ORCID: https://orcid.org/0000-0001-5588-0277)
- John H. Maduro (ORCID: https://orcid.org/0000-0003-2458-8702)
- Marita Partanen (ORCID: https://orcid.org/0000-0003-1018-9778)
- Eelco W. Hoving (ORCID: https://orcid.org/0000-0002-5587-0439)
- Anne E M Leenders (ORCID: https://orcid.org/0000-0002-9737-6535)
- Bruno M. de Brito Robalo
- Maarten Lequin
Institutions
- Leiden University (NL)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Princess Máxima Center (NL)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1016/j.ynirp.2025.100301
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00