Network pharmacology-based analysis of the antithrombotic clinical efficacy and antithrombotic mechanism of Huoxue Jiedu prescription in the treatment of polycythemia vera with heat toxin and blood stasis syndrome.
Network pharmacology predicted the corresponding targets of traditional Chinese medicine to a certain extent. Huoxue Jiedu prescription could enhance clinical efficacy, improve hematological indicators, and reduce coagulation indicators through antithrombotic effect by inhibiting the expression of PI3K and AKT1.
Authors
- Haixia Duan
- Yuliang Zhang (ORCID: https://orcid.org/0000-0002-9191-6019)
- Mengjun Zhao
- Zhaoxia Liu (ORCID: https://orcid.org/0000-0003-1188-6823)
- Zhao Yu-min
- Wang Guozi
- Liu Xizan
- Zhao Pengmin
Institutions
- Hebei North University (CN)
- Zhangjiakou Academy of Agricultural Sciences (CN)
- Langfang Normal University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.06.014
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00