Artificial oocytes through haploidization of mouse endometrial stromal cells and bone marrow-derived mesenchymal stem cells
Somatic cell haploidization of EmSCs and BM-MSCs generated oocytes capable of full preimplantation development and yielded healthy offspring. The utilization of genotyped donor nuclei for neogametogenesis may represent a feasible fertility treatment option for individuals with complete absence of oocytes.
Authors
- Gianpiero D. Palermo (ORCID: https://orcid.org/0000-0001-8440-4560)
- Shelun Tsai (ORCID: https://orcid.org/0000-0003-1487-9039)
- Stephanie Cheung (ORCID: https://orcid.org/0000-0002-2092-7001)
- Philip Xie (ORCID: https://orcid.org/0009-0000-1378-2919)
- Zev Rosenwaks
Institutions
- Hospital for Special Surgery (US)
- Cornell University (US)
- Northwest Clinical Research Center (US)
Publication Details
- Journal
- F&S Science
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1016/j.xfss.2025.12.002
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00