Photoredox/Brønsted Acid-Catalyzed Asymmetric Difluoroalkylation/Rearrangement of Alkenylfurans
A catalytic asymmetric difluoroalkylation/rearrangement of alkenylfurans with difluoroalkyl sulfones and anilines has been developed. This method employs cooperative photoredox/Brønsted acid catalysis, enabling efficient and versatile synthesis of difluoroalkyl-containing 4-aminocyclopentenones with excellent diastereo- and enantioselectivities.
Authors
- Yunfei Cai (ORCID: https://orcid.org/0000-0003-4823-8221)
- Menghan Qin
- Kexin Yang (ORCID: https://orcid.org/0000-0003-2333-2406)
- Yurong Tang (ORCID: https://orcid.org/0000-0002-4183-8008)
Institutions
- Chongqing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1021/acs.orglett.5c04775
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00