PHARMACOKINETIC AND PHARMACODYNAMIC ALTERATIONS OF LOCAL ANESTHETICS IN PATIENTS WITH SYSTEMIC DISORDERS: A NARRATIVE REVIEW.
Since systemic diseases can significantly modify the bioavailability, metabolism, and pharmacokinetics of local anesthetics, anesthetic protocols should be individualized for each patient based on their specific comorbid condition and metabolic status.
Authors
- Erdinç Aydın (ORCID: https://orcid.org/0000-0002-0843-3201)
- Virginia J. Savin (ORCID: https://orcid.org/0000-0002-9454-5217)
- З. С. Хабадзе (ORCID: https://orcid.org/0000-0002-7257-5503)
- A. N. Vavilova
- N. A. Dolzhikov (ORCID: https://orcid.org/0009-0006-3781-363X)
- G. G. Avetisian (ORCID: https://orcid.org/0009-0003-7647-4958)
- D. F. Rasulova (ORCID: https://orcid.org/0009-0004-0257-2958)
- D. D. Khubulova (ORCID: https://orcid.org/0009-0000-3772-7324)
- E Starodubtseva (ORCID: https://orcid.org/0000-0002-0702-8036)
- D Pervozvanova
- P Pogodina
Institutions
- Peoples' Friendship University of Russia (RU)
Publication Details
- Journal
- PubMed
- Published
- 2025-10-01
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00