Exploring a panel of serum biomarkers for cancer risk in patients with non-specific symptoms: a comparative analysis of feature selection methods
Biomarker-based scores effectively identified NSS patients at higher cancer risk. LCA captured a broader biomarker range, offering higher sensitivity, while LASSO achieved higher specificity with fewer markers. These scores may also help detect severe benign conditions, improving RDC triage. Further validation is needed before broader clinical implementation.
Authors
- Mieke Van Hemelrijck (ORCID: https://orcid.org/0000-0002-7317-0858)
- Maria J. Monroy‐Iglesias (ORCID: https://orcid.org/0000-0003-2417-3275)
- Aida Santaolalla
- Geraint Jones
- Bernard V. North (ORCID: https://orcid.org/0000-0001-9504-2294)
- F Bruno (ORCID: https://orcid.org/0000-0002-4037-4790)
- Kate Haire
- Saoirse Dolly (ORCID: https://orcid.org/0000-0002-3401-318X)
- Charlotte Louise Moss (ORCID: https://orcid.org/0000-0002-4354-8987)
- Lindsay Steward
- Chandra Basyal
- Carlos Cargaleiro
- Beth Russell (ORCID: https://orcid.org/0000-0001-5640-8425)
- Juliet Millwaters
- Sabine Martin
- Sarah Weild
Institutions
- Guy's and St Thomas' NHS Foundation Trust (GB)
- London Cancer (GB)
- Lewisham and Greenwich NHS Trust (GB)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/bmjopen-2025-099967
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research UK