Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3): 10-Year Clinical Outcomes and Post Hoc Analysis by Molecular Classification From a Randomized Phase 3 Trial
(Abstracted from Lancet Oncol 2025;26(10):1370-1381) Fifteen percent to 20% of endometrial cancer patients have a high-risk form of the disease; this classification indicates a higher risk of cancer recurrence and cancer-related death. The standard therapy for high-risk endometrial cancer is pelvic radiotherapy.
Authors
- Viet Do (ORCID: https://orcid.org/0000-0003-1386-0758)
- Henry C Kitchener (ORCID: https://orcid.org/0000-0001-5791-7838)
- Alicia León‐Castillo (ORCID: https://orcid.org/0000-0003-0873-5362)
- Remi A. Nout (ORCID: https://orcid.org/0000-0001-8011-2982)
- Jeanette M. Bouma
- Tjalling Bosse (ORCID: https://orcid.org/0000-0002-6881-8437)
- Alexandra Léary (ORCID: https://orcid.org/0000-0002-2043-2244)
- Dionyssios Katsaros (ORCID: https://orcid.org/0000-0002-8267-1494)
- Mary McCormack (ORCID: https://orcid.org/0000-0002-8429-5744)
- Cathalijne Post (ORCID: https://orcid.org/0000-0003-2534-6887)
- Romerai D’Amico
- Stephanie M. de Boer (ORCID: https://orcid.org/0000-0002-8454-1597)
- Ina M. Jürgenliemk‐Schulz (ORCID: https://orcid.org/0000-0003-4911-006X)
- Ludy Lutgens (ORCID: https://orcid.org/0000-0002-2942-8858)
- Petronella B. Ottevanger (ORCID: https://orcid.org/0000-0001-8209-487X)
- Paul Bessette
- Linda Mileshkin (ORCID: https://orcid.org/0000-0001-6826-6014)
- Hans W. Nijman (ORCID: https://orcid.org/0000-0002-1821-3042)
- Cyrus Chargari (ORCID: https://orcid.org/0000-0003-0119-3695)
- Hein Putter (ORCID: https://orcid.org/0000-0001-5395-1422)
- Carien L. Creutzberg (ORCID: https://orcid.org/0000-0002-7008-4321)
- Melanie Powell (ORCID: https://orcid.org/0000-0002-9850-8181)
- Anthony Fyles (ORCID: https://orcid.org/0000-0002-3633-2483)
- Pearly Khaw (ORCID: https://orcid.org/0000-0002-1474-0881)
- Amanda Feeney
- Andrea Alberto Lissoni
- Karen Whitmarsh
- Diane Procencher
- Catherine Genestrie
Institutions
- Radboud University Nijmegen (NL)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Peter MacCallum Cancer Centre (AU)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Obstetrical & Gynecological Survey
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/ogx.0000000000001475
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00