Hypoglycemic mechanism of modified Gegen Qinlian decoction based on regulating the expression and DNA methylation of cholesterol transporters in the adipose tissue of type 2 diabetes mellitus rats.
MGQD did not significantly affect LDLR and SR-B1 expression or gene methylation in iWAT. However, its hypoglycemic effect may be linked to cholesterol regulation in eWAT. Potential mechanisms include increased LDLR protein levels, which may enhance cholesterol uptake, and increased <i>Srb1</i> methylation, which may suppress its expression and consequently reduce cholesterol efflux.
Authors
- Shuhong Peng (ORCID: https://orcid.org/0000-0002-2400-7763)
- Peng‐Cheng Yao (ORCID: https://orcid.org/0000-0002-8802-1345)
- Weifeng Zhu (ORCID: https://orcid.org/0009-0003-9970-9932)
- Mengyu Zhang (ORCID: https://orcid.org/0000-0001-9375-6664)
- Changhua Zhang
- Xin-Yi Liu (ORCID: https://orcid.org/0000-0003-2722-4795)
- Guoliang Xu (ORCID: https://orcid.org/0000-0003-0610-8891)
- Yang Lingkun
- Lin Seqi
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.06.006
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00