Robust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization
Surface demineralization enabled strong adhesion of the solid-state HAp adhesive to bone by exposing collagen swollen with water. Adhesion strength was influenced by structural changes in the demineralized layer, and the adhesive provided stable <i>in vivo</i> fixation, supporting its potential for bone-anchored biomedical applications.
Authors
- Masahiro Okada (ORCID: https://orcid.org/0009-0002-7637-2639)
- Xiaofeng Yang (ORCID: https://orcid.org/0000-0001-5012-5651)
- Takayoshi Nakano (ORCID: https://orcid.org/0000-0001-8052-1698)
- Akihisa Otaka (ORCID: https://orcid.org/0000-0002-0594-2422)
- Suhong Xie (ORCID: https://orcid.org/0000-0003-1044-9373)
- Haruyuki Aoyagi (ORCID: https://orcid.org/0009-0002-9937-8363)
- Takuya Matsumoto (ORCID: https://orcid.org/0000-0002-9804-4786)
Institutions
- Okayama University (JP)
- Tohoku University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1016/j.bioactmat.2025.11.030
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00