Joint Effects of Anticholinergic Burden and Neurofilament Light on Dementia Risk: The Shanghai Aging Study
These findings identify plasma NfL as a critical modifier of anticholinergic-related cognitive vulnerability, providing mechanistic insights for risk stratification and supporting biomarker-guided deprescribing strategies in older adults exposed to ACDs.
Authors
- Bin Wang (ORCID: https://orcid.org/0000-0002-1164-8430)
- Danyi Chi (ORCID: https://orcid.org/0009-0004-8618-9349)
- Qianhua Zhao (ORCID: https://orcid.org/0000-0001-5655-158X)
- Zhenxu Xiao (ORCID: https://orcid.org/0000-0002-6598-0367)
- Ding Ding (ORCID: https://orcid.org/0000-0002-3260-7515)
- Xiaoniu Liang (ORCID: https://orcid.org/0000-0002-4542-2202)
- Xiaowen Zhou
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cns.70691
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Ministry of Education, India
- Shanghai Hospital Development Center
- Huashan Hospital