Species distribution, antifungal susceptibility, and clinical profiles of patients with osteoarticular fungal Infections: A retrospective study

We concluded that <i>Candida albicans</i> and <i>Aspergillus fumigatus</i> as the predominant pathogens in OAFIs, while rare species including <i>Cryptococcus neoformans</i>, <i>Lomentospora prolificans</i>, and <i>Cryptococcus laurentii</i> were also isolated from OAFI cases. Antifungal susceptibility testing revealed VRC and POS as potentially effective therapeutic options for OAFIs. These findings underscore the need for early detection of rare fungal pathogens, susceptibility-guided therapy, and continuous resistance surveillance in managing OAFIs in non-immunodeficient patients.