Patterns of immune-related adverse events and treatment responses in adolescents and young adults with melanoma during initial and rechallenge immune checkpoint inhibitor therapy
AYA patients receiving ICI therapy for melanoma had high incidence of colitis and hepatitis and favorable survival. Initial and rechallenge ICI therapy had similar patterns of irAE severity and efficacy. Colitis and hepatitis were associated with improved OS.
Authors
- Ida John (ORCID: https://orcid.org/0009-0006-0279-1557)
- Michael Roth (ORCID: https://orcid.org/0000-0002-6411-8353)
- Jiasen He (ORCID: https://orcid.org/0000-0001-7479-4315)
- Clark R. Andersen (ORCID: https://orcid.org/0000-0003-1846-9117)
- Jennifer L. McQuade (ORCID: https://orcid.org/0000-0002-2393-2172)
- Yinghong Wang (ORCID: https://orcid.org/0000-0002-5148-6130)
- Mianen Sun (ORCID: https://orcid.org/0000-0003-0535-5831)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-012337
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Texas MD Anderson Cancer Center