The aging of the AlphaFold database
The AlphaFold database, released in 2022, modeled UniProt sequences from April 2021 and now provides 200 million predicted protein structures. Of the 20,504 full-length predicted human structures, 631 entries conflict with the June 2025 UniProt release. Similar conflicts across species highlight how bioinformatics resources can rapidly age.
Authors
- Michael J.E. Sternberg (ORCID: https://orcid.org/0000-0002-1884-5445)
- Ifigenia Tsitsa (ORCID: https://orcid.org/0000-0001-8154-5528)
- Anja Conev (ORCID: https://orcid.org/0000-0001-9049-0266)
- Alessia David (ORCID: https://orcid.org/0000-0001-8687-024X)
- Suhail A. Islam (ORCID: https://orcid.org/0000-0001-6847-9730)
Institutions
- Imperial College London (GB)
Publication Details
- Journal
- Nature Structural & Molecular Biology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1038/s41594-025-01725-z
- Citations
- 1
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.76