Persistence of Vascular Calcification: A Failure of Cell-Mediated Resorption
Hydroxyapatite is readily reabsorbed in vivo by a cell-mediated process not involving osteoclasts. The lack of resorption of medial arterial calcifications, even in the presence of osteoclasts, indicates that calcifications have properties that prevent cell-mediated resorption. Further studies are needed to identify these properties and develop strategies to overcome this.
Authors
- Sadaf Dabeer (ORCID: https://orcid.org/0000-0002-0564-4185)
- W. Charles O’Neill (ORCID: https://orcid.org/0000-0001-7741-4568)
- Xiaonan H. Wang (ORCID: https://orcid.org/0000-0002-1023-8499)
- M. Neale Weitzmann (ORCID: https://orcid.org/0000-0003-3305-5748)
- Ying Huang (ORCID: https://orcid.org/0000-0001-6360-415X)
Institutions
- Emory Healthcare (US)
- St. Joseph’s Healthcare Hamilton (CA)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1161/atvbaha.125.323136
- Citations
- 1
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.43