Enrichment of the commensal microbiome in the lower respiratory tract is associated with improved outcomes following lung transplantation
The composition of the lung microbiome may serve as a prognostic biomarker for clinical outcomes after lung transplantation. The presence of diverse, commensal-dominated communities was associated with improved outcomes, whereas viral enrichment correlated with adverse events. These findings underscore the clinical importance of microbiome monitoring in posttransplant management and suggest that targeted modulation of microbial communities could improve long-term graft stability and patient prognosis.
Authors
- Yang Ni (ORCID: https://orcid.org/0000-0002-3472-386X)
- Bin Cao (ORCID: https://orcid.org/0000-0001-6513-1800)
- Baoshan Xing (ORCID: https://orcid.org/0000-0003-2028-1295)
- Mengyin Chen
- Kang Chang (ORCID: https://orcid.org/0000-0003-1214-0695)
- Qing Zhang (ORCID: https://orcid.org/0000-0002-5200-3356)
- Chun Wang (ORCID: https://orcid.org/0000-0002-8233-6055)
- Wenhui Chen (ORCID: https://orcid.org/0000-0002-6419-2713)
- Lijuan Guo (ORCID: https://orcid.org/0000-0002-4992-4859)
- Zhao Li (ORCID: https://orcid.org/0000-0003-2281-8332)
- X. Zou (ORCID: https://orcid.org/0000-0003-0607-4759)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Chinese Medical Journal - Pulmonary and Critical Care Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.pccm.2025.11.006
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00