Bidirectional relations between the maternal and infant gut microbiome and behavior
How the gut microbiome influences maternal mental health and infant behavior remains poorly understood. We measured mothers' and infants' gut microbiota composition and behavior across the first year of the infant's life. Individual taxa from the infant, but not the maternal, gut were associated with infant behavioral temperament. Our findings provide evidence for complex bidirectional gut-behavior associations between mothers and infants.
Authors
- Robert Moulder (ORCID: https://orcid.org/0000-0001-7504-9560)
- Stephanie Prescott (ORCID: https://orcid.org/0000-0002-0469-5255)
- John A. McCulloch (ORCID: https://orcid.org/0000-0001-7107-6561)
- Caitlin Dreisbach (ORCID: https://orcid.org/0000-0003-3964-3161)
- Jeanne L. Alhusen (ORCID: https://orcid.org/0000-0001-9492-1932)
- Tobias Großmann (ORCID: https://orcid.org/0000-0002-1116-6423)
- Giorgio Trinchieri (ORCID: https://orcid.org/0000-0001-5892-7464)
- Caroline Kelsey (ORCID: https://orcid.org/0000-0001-8384-023X)
- Heath Yancey (ORCID: https://orcid.org/0009-0009-4845-147X)
Institutions
- Boston Children's Hospital (US)
- National Institutes of Health (US)
- University of Illinois Urbana-Champaign (US)
- University of Colorado Boulder (US)
- Inova Children's Hospital (US)
- National Cancer Institute (US)
- University of Virginia (US)
- University of Rochester (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1038/s41390-025-04630-9
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Science Foundation
- Danone
- Jefferson Scholars Foundation
- National Institutes of Health
- National Cancer Institute