A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem
This study emphasizes the role of alternative splicing in glioma cellular heterogeneity, highlighting the importance of an isoform-centric approach to better understand the complex biological processes driving tumorigenesis.
Authors
- Deanna Tiek (ORCID: https://orcid.org/0000-0002-2881-7691)
- Qiu He
- Xiao Song (ORCID: https://orcid.org/0000-0002-3171-4300)
- Shi‐Yuan Cheng (ORCID: https://orcid.org/0000-0003-1737-0588)
- Runxin Wu (ORCID: https://orcid.org/0009-0001-4417-2694)
- Bo Hu (ORCID: https://orcid.org/0000-0001-8601-8284)
- Maya Walker
- Xiaozhou Yu (ORCID: https://orcid.org/0000-0002-9187-2896)
- Minghui Lu (ORCID: https://orcid.org/0000-0002-7863-5255)
- Derek Sisbarro
Institutions
- Cleveland Clinic (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Genome biology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s13059-025-03889-9
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Northwestern University
- National Institutes of Health
- U.S. Army
- Robert H. Lurie Comprehensive Cancer Center
- U.S. Army Medical Research Acquisition Activity