Mechanics-guided parametric modeling of intranasal spray devices and formulations for targeted drug delivery to the nasopharynx
The overall findings, while implicitly tied to the two test subjects (i.e., for spray administration through four representative nasal pathways), do collectively demonstrate that rational optimization of the intranasal sprays for targeted nasopharyngeal deposition is attainable with actionable design modifications on the sprayed droplet sizes and device plume angles.
Authors
- Saikat Basu (ORCID: https://orcid.org/0000-0003-1464-8425)
- Azadeh A. T. Borojeni (ORCID: https://orcid.org/0000-0002-8488-2615)
- Sunghwan Jung (ORCID: https://orcid.org/0000-0002-1420-7921)
- Damayanti Samanta (ORCID: https://orcid.org/0000-0002-3510-0314)
- Gerallt Williams
- Joshua Reineke (ORCID: https://orcid.org/0000-0002-1788-862X)
- Gonçalo Farias (ORCID: https://orcid.org/0000-0001-9717-4565)
- Mohammad Mehedi Hasan Akash (ORCID: https://orcid.org/0000-0001-7520-0531)
- Mazeda Hossain (ORCID: https://orcid.org/0000-0002-1878-8145)
- Mohammed Yeasin (ORCID: https://orcid.org/0000-0003-0579-3030)
- William O’Connell (ORCID: https://orcid.org/0000-0001-5634-0088)
- Abir Malakar
- Julie Suman
Institutions
- Indian Institute of Technology Ropar (IN)
- Florida A&M University - Florida State University College of Engineering (US)
- South Dakota State University (US)
- Cornell University (US)
- Aptar (United States) (US)
- Clinical Research Solutions (US)
- Aptar (France) (FR)
Publication Details
- Journal
- Frontiers in Drug Delivery
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fddev.2025.1721960
- Citations
- 1
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.52