To Explore the Mechanism of Cuproptosis in Psoriasis Based on Bioinformatics and in vivo Experiments
APOL6, CD274, and LIAS were screened as cuprotosis markers in psoriasis. Overexpression of these PDCRGs in psoriasis model mice can promote copper ion accumulation and interfere with the TCA cycle, increase oxidative stress and inflammation levels, and ultimately lead to the occurrence of psoriasis. Therefore, targeted intervention of cuprotosis is of great significance for the clinical treatment of psoriasis.
Authors
- Suqing Yang (ORCID: https://orcid.org/0000-0003-3630-3129)
- Jintong Yao
- Jian Zhang (ORCID: https://orcid.org/0000-0002-1475-2276)
- Hailiang Wang (ORCID: https://orcid.org/0000-0002-6668-7947)
- Yingying Ma (ORCID: https://orcid.org/0000-0002-6245-2200)
- Ying Sun
Institutions
- Northeast Electric Power University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Changchun University of Chinese Medicine (CN)
- Jilin Electric Power Research Institute (China) (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s569453
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00