Iloprost, a Prostacyclin Analogue, Alleviates Oxidative Stress and Improves Development of Parthenogenetic Porcine Embryos via Nrf2/Keap1 Signaling
This study demonstrates that PGI<sub>2</sub> protects embryos by activating Nrf2/Keap1 signaling, establishing this axis as a key antioxidant defense during embryonic development and highlighting its potential to improve embryo culture systems.
Authors
- Sun‐Uk Kim (ORCID: https://orcid.org/0000-0002-5168-6976)
- Kyung Seob Lim (ORCID: https://orcid.org/0000-0002-9117-887X)
- Se‐Been Jeon (ORCID: https://orcid.org/0009-0005-1944-8299)
- Kyungjun Uh (ORCID: https://orcid.org/0000-0001-8893-1034)
- Seong‐Keun Cho (ORCID: https://orcid.org/0000-0001-9309-2327)
- Bong‐Seok Song (ORCID: https://orcid.org/0000-0002-0489-6719)
- Pil‐Soo Jeong (ORCID: https://orcid.org/0000-0002-8477-4358)
- Yu An (ORCID: https://orcid.org/0000-0002-9678-3382)
- Ji Hyeon Yun
- Eun Young Choi (ORCID: https://orcid.org/0000-0002-1668-6452)
- Hyo‐Gu Kang
- Hee-Chang Son
- S. Lee (ORCID: https://orcid.org/0000-0003-2511-6723)
Institutions
- Chungbuk National University (KR)
- Gyeongsang National University (KR)
- Chungnam National University (KR)
- Pusan National University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Antioxidants
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3390/antiox14121493
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Research Institute of Bioscience and Biotechnology
- Ministry of Education, Science and Technology
- Ministry of Science and ICT, South Korea