Fetal programming by the parental microbiome of offspring behavior, and DNA methylation and gene expression within the hippocampus
Collectively, these data provide proof-of-principle that the maternal gut microbiome has a dominant influence on the neurodevelopment underlying certain offspring behaviors and activities, and selectively affects genome DNA methylation and gene expression in the offspring hippocampus in conjunction with that neurodevelopment. Video Abstract.
Authors
- Craig L. Franklin (ORCID: https://orcid.org/0000-0002-9198-867X)
- Zachary L. McAdams (ORCID: https://orcid.org/0000-0003-2883-507X)
- James Amos‐Landgraf (ORCID: https://orcid.org/0000-0003-2535-7746)
- Kevin L. Gustafson (ORCID: https://orcid.org/0000-0002-2104-8762)
- Aaron C. Ericsson (ORCID: https://orcid.org/0000-0002-3053-7269)
- Nathan J. Bivens (ORCID: https://orcid.org/0000-0002-6023-8729)
- Rene Cortese (ORCID: https://orcid.org/0000-0001-9262-7828)
- Pavlo Khodakivskyi (ORCID: https://orcid.org/0000-0002-9230-5412)
- Paul Wilmes (ORCID: https://orcid.org/0000-0002-6478-2924)
- Susheel Bhanu Busi (ORCID: https://orcid.org/0000-0001-7559-3400)
- Lyndon M. Coghill (ORCID: https://orcid.org/0000-0002-6258-9194)
- Elena A. Goun (ORCID: https://orcid.org/0000-0002-4214-0656)
- Rachael E. McCorkle
- Murugesan Raju (ORCID: https://orcid.org/0000-0002-2618-8027)
- Daniel J. Davis (ORCID: https://orcid.org/0000-0002-6287-4315)
Institutions
- University of Luxembourg (LU)
- Missouri College (US)
- University of Missouri Health System (US)
- UK Centre for Ecology & Hydrology (GB)
- Luxembourg Institute of Science and Technology (LU)
- University of Missouri (US)
Publication Details
- Journal
- Microbiome
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s40168-025-02226-3
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- University of Missouri