Rhodium( <scp>ii</scp> )-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions
We integrate a recyclable Rh-MOF heterogeneous catalyst into carbene-mediated three-component reactions of diazo compounds, alcohols and electrophiles. This system exhibits broad functional group tolerance, excellent diastereoselectivity, and high turnover number (TON = 856), while enabling continuous-flow gram-scale synthesis with prolonged operational stability.
Authors
- Cheng‐Yong Su (ORCID: https://orcid.org/0000-0003-3604-7858)
- Zhuodi Chen
- Wenhao Hu (ORCID: https://orcid.org/0000-0003-1511-2614)
- Chunan Wang (ORCID: https://orcid.org/0000-0003-0810-6400)
- Haiqing Wang (ORCID: https://orcid.org/0000-0002-6805-2283)
- Xinke Zhang (ORCID: https://orcid.org/0000-0002-1215-3296)
- Xiang Fu (ORCID: https://orcid.org/0009-0003-1691-6283)
- Hekun Huang (ORCID: https://orcid.org/0009-0005-0624-8386)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
- Institute of Molecular Functional Materials (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1039/d5ob01742d
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00