Age-related alterations in regional cerebrovascular reactivity: mediation by grey matter atrophy and association with cognitive performance
Resting-state CVR demonstrated regionally heterogeneous age-related decreases or increases, partly mediated by GM atrophy. In older adults, CVR in age-sensitive regions was selectively associated with executive function through linear and nonlinear patterns. Cerebrovascular ageing may involve region-specific vascular adaptations and macrostructural-microvascular (GM-CVR) interactions. Region- and range-dependent CVR could serve as a biomarker for executive function changes.
Authors
- Qihui Wang (ORCID: https://orcid.org/0000-0003-3768-0401)
- Xiuqin Jia
- Qi Yang (ORCID: https://orcid.org/0000-0002-5773-0456)
- Xuejia Jia (ORCID: https://orcid.org/0000-0001-5515-2245)
- Yifei Zhang (ORCID: https://orcid.org/0000-0003-0272-0602)
- Jiajia Zhang (ORCID: https://orcid.org/0000-0003-1201-3987)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Capital Medical University (CN)
- General Electric (Spain) (ES)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
Publication Details
- Journal
- Age and Ageing
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1093/ageing/afaf353
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00