VAL-083 is effective in patients with newly-diagnosed MGMT-unmethylated glioblastoma: report of phase II study
VAL-083 (30 mg/m<sup>2</sup>/day) combined with radiation therapy was generally safe and well tolerated. Adverse events aligned with previous studies. This regimen, compared to standard-of-care TMZ, showed potential benefits in terms of disease progression and overall survival. Trial registration ClinicalTrials.gov ID NCT03050736, dated: February 13, 2017.
Authors
- Ke Sai (ORCID: https://orcid.org/0000-0003-1762-9019)
- Fuhua Lin
- Jeffrey Bacha (ORCID: https://orcid.org/0009-0009-0800-6208)
- Shaoyan Xi
- Ziyu Dai (ORCID: https://orcid.org/0000-0003-2855-741X)
- Claire Kwan
- Xiaoling Qiu (ORCID: https://orcid.org/0000-0003-0838-8356)
- Xiaojing Du (ORCID: https://orcid.org/0000-0001-8228-5086)
- Wanming Hu
- John Langlands (ORCID: https://orcid.org/0009-0006-3200-5465)
- Yanchun Lv (ORCID: https://orcid.org/0000-0003-1671-2355)
- Qunying Yang (ORCID: https://orcid.org/0000-0002-4196-440X)
- Zhenghe Chen
- Dennis Brown (ORCID: https://orcid.org/0000-0002-5011-7798)
- Richard Schwartz (ORCID: https://orcid.org/0000-0002-4654-624X)
- Sarath Kanekal
- Ji Zhang (ORCID: https://orcid.org/0000-0002-1244-2880)
- Xi Cao (ORCID: https://orcid.org/0000-0002-9650-3897)
- Chao Ke (ORCID: https://orcid.org/0000-0003-1918-9600)
- Yixiang Liao (ORCID: https://orcid.org/0000-0002-4313-9315)
- Zhihuan Zhou (ORCID: https://orcid.org/0000-0002-1738-064X)
- Glyn Johnson (ORCID: https://orcid.org/0000-0001-6826-5054)
- Jiawei Li (ORCID: https://orcid.org/0000-0001-9957-8192)
- Chengcheng Guo (ORCID: https://orcid.org/0009-0003-2122-7001)
- Shaoxiong Wu (ORCID: https://orcid.org/0000-0002-9388-6239)
- Zhongping Chen
- Meiling Deng
Institutions
- Sun Yat-sen University (CN)
- Vale (Brazil) (BR)
- Technology Holding (United States) (US)
- Delmar (Canada) (CA)
- Sun Yat-sen University Cancer Center (CN)
- Applied Sciences Laboratory (United States) (US)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1007/s12672-025-04235-y
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00