NAD <sup>+</sup> Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1‐Mediated Mitochondrial Function via NAMPT
NAD<sup>+</sup> enhances the therapeutic effect of MSCs on D-gal-induced muscle atrophy by promoting NAMPT secretion, which acts on the SIRT1 signaling pathway, and improves mitochondrial function and fatty acid oxidation in skeletal muscles. This study provides new insights and a theoretical basis for clinical treatment of sarcopenia.
Authors
- Jun Cheng (ORCID: https://orcid.org/0000-0001-6451-6629)
- Nan Zang (ORCID: https://orcid.org/0000-0001-5561-8068)
- Xinguo Hou (ORCID: https://orcid.org/0000-0003-2045-1290)
- Jie Chen (ORCID: https://orcid.org/0000-0002-7773-3160)
- Xue Liu (ORCID: https://orcid.org/0000-0002-3697-9893)
- Li Chen (ORCID: https://orcid.org/0000-0001-8492-1963)
- Jun Chen (ORCID: https://orcid.org/0000-0002-2362-5359)
- Kewei Wang (ORCID: https://orcid.org/0000-0001-6504-5750)
- Fuqiang Liu
- Wenjian Zhang (ORCID: https://orcid.org/0000-0002-3524-3841)
- Yuting Sun
- Ruxing Zhao (ORCID: https://orcid.org/0000-0002-8893-1007)
- Longqing Xia
- Jia Song
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70142
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00